Founded in 1975, it includes Guangming Hospital District, Futian Hospital District, acupuncture hospital and "one hospital and four districts" of science and education center. Its subordinate institutions include Shenzhen Institute of traditional Chinese medicine, Shenzhen Window of Chinese medicine talent training center, and Shenzhen traditional Chinese medicine preparation center. In 1995, the hospital became one of the first class III class a traditional Chinese medicine hospitals in China; In 1998, it became the first non directly affiliated hospital of Guangzhou University of traditional Chinese medicine; In 2012, it became the Fourth Clinical Medical College of Guangzhou University of traditional Chinese medicine; In 2019, it became the Shenzhen Hospital Affiliated to Nanjing University of traditional Chinese medicine; In 2021, it was selected as the key construction Hospital of high-level hospitals in Guangdong Province. In the performance evaluation of national level 3 public hospitals, it has obtained the national monitoring index grade a+ for two consecutive years, and passed the national interconnection standardization maturity grade 5 grade B. It is the only traditional Chinese medicine hospital in China that has passed the level 6 electronic medical record review.

The hospital has more than 2500 employees, including more than 2300 health technicians, more than 600 people with senior titles, and nearly 60 national, provincial and municipal famous and excellent traditional Chinese medicine. The total value of medical equipment in the hospital is more than 800million yuan, and it has a number of scientific research MRI and CT machines, digital operating rooms, 3D laparoscopy, four-dimensional high-end color ultrasound and other sophisticated medical equipment. At present, the hospital has an annual outpatient and emergency volume of more than 2.1 million people, nearly 1000 open beds, and an annual discharge of 40000 patients. The hospital is the leading unit of South China traditional Chinese medicine liver disease diagnosis and Treatment Center Alliance, Shenzhen traditional Chinese medicine medical alliance, Shenzhen preventive treatment alliance, Shenzhen traditional Chinese medicine andrology medical technology professional alliance, Guangdong Hong Kong Macao Dawan District traditional Chinese medicine clinical inheritance and Innovation Research Center anti gout alliance, and Shenzhen traditional Chinese medicine nursing regional alliance.